Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.5
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.9
Supplement Facts
Serving Size:  2 Veg Capsules
Amount Per Serving
%DV
Magnesium (from Magnesium Aspartate)
250 mg
60%
Potassium (from Potassium Aspartate)
99 mg
2%
Taurine (Free-Form)
100 mg

Top Medical Research Studies

9
M-channel activation mitigates arrhythmias
We examined whether activating M-type potassium channels in the left stellate ganglion could help manage heart issues during acute myocardial ischemia (AMI). In our study involving beagles, some received an M-channel activator called retigabine before inducing AMI.

The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
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8
Magnesium's impact on heart health
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.

Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.

Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
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8
Taurine improves heart health metrics
We explored the potential benefits of taurine, an amino acid that could play a significant role in promoting cardiovascular health. Our investigation focused on how taurine treatment affects key aspects of heart function, including blood pressure, heart rate, and overall cardiac performance.

By analyzing data from several randomized controlled trials, we aimed to get a clearer picture of taurine's effects. Our study looked at important metrics such as systolic and diastolic blood pressure, heart rate, and the left ventricular ejection fraction, which are all critical indicators of heart health.

The findings indicated that taurine is helpful in preventing hypertension and can improve cardiac function, making it a beneficial addition for those at risk of cardiovascular diseases. Overall, incorporating taurine into daily routines might be advantageous for heart health, particularly for individuals prone to cardiovascular issues.
Read More

Most Useful Reviews

9
Optimises cardiovascular health
1 people found this helpful
NOW Foods Magnesium & Potassium Aspartate is a robust supplement blend for overall health. Its neutral scent allows easy incorporation into daily life. The formulation combines magnesium and potassium aspartate, working together to support muscle function, electrolyte balance, and overall cardiovascular health. The generous quantity ensures optimal daily intake. The practical packaging is easy to store and consume, aiding not just muscle and heart health, but also nerve function and energy production. Overall, it's an essential for anyone wanting comprehensive mineral support.
Read More
9
Tangible benefits
1 people found this helpful
I purchased this supplement for my husband on a doctor's recommendation. The benefits are tangible; my night cramps diminished almost immediately and my sleep improved. It contains taurine for additional health support. The large packaging will last a long time, and the ingredients—magnesium, potassium, and taurine—are exactly what I need for cardiovascular and nervous system support. The quality is excellent, the capsules are manageable to swallow, and the taste is neutral. I recommend it.
Read More
9
Restores cardiovascular system
Excellent product quality with natural ingredients. The capsules are convenient in size. It aids the restoration of joints, muscles, and the proper functioning of the entire cardiovascular system.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.5
  • All Researches
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.

In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.

Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
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We investigated how ICA-105574, an HERG channel activator, might alleviate severe long QT syndrome type 2 (LQT2) caused by critical genetic mutations. Our study included in vivo experiments with animal models and in vitro tests that showcased ICA-105574's ability to shorten cardiac repolarization intervals.

We found it effectively restored ion currents impacted by harmful mutations. Our findings indicate that ICA-105574 has potential as a therapeutic option and highlight the usefulness of molecular dynamics simulations in drug design for managing HERG-related conditions.
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9
AMPK activation improves endothelial function
We explored how AMPK, when activated, enhances potassium channels known as K2.3 in endothelial cells, which could improve vascular health. Through various laboratory techniques, we found that AMPK activation increased the phosphorylation of K2.3, leading to better blood flow in mouse models of hypertension. This process seems to reduce early hypertension caused by angiotensin II. Our findings suggest that AMPK could be a valuable target for therapies aimed at treating endothelial dysfunction and hypertension.
Read More
9
M-channel activation mitigates arrhythmias
We examined whether activating M-type potassium channels in the left stellate ganglion could help manage heart issues during acute myocardial ischemia (AMI). In our study involving beagles, some received an M-channel activator called retigabine before inducing AMI.

The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
Read More
9
Taurine and EMIQ mitigate cardiotoxicity
We investigated how taurine (Tau) and enzymatically modified isoquercitrin (EMIQ) can help protect the heart from damage caused by methotrexate (MTX), a common cancer treatment associated with cardiotoxic effects. Our study involved adult male rats that were divided into several groups, each receiving different treatments. Among these groups, some rats were given MTX alone, while others received combinations of Tau and EMIQ alongside MTX.

Our findings revealed that MTX significantly impacted heart function, leading to abnormal heart rhythms and increased inflammation in cardiac tissues. Specifically, we saw changes in heart electrical signals, such as shortened intervals between heartbeats and an extended duration for the heart's repolarization process, indicating potential cardiac distress.

However, when we treated the rats with Tau and EMIQ, either alone or together, we observed an impressive protective effect against these adverse changes. Both treatments helped improve heart conductivity and rhythm, while also reducing inflammation and cell damage within the heart. This suggests that incorporating these compounds into treatment regimens might help mitigate some of the heart-related side effects of MTX therapy.

Our results highlight the potential benefits of taurine and EMIQ, particularly when used in combination, for maintaining heart health during cancer treatment. This research sheds light on promising nutritional approaches to counteract cardiotoxicity in cancer therapies.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 10 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Optimises cardiovascular health
1 people found this helpful
NOW Foods Magnesium & Potassium Aspartate is a robust supplement blend for overall health. Its neutral scent allows easy incorporation into daily life. The formulation combines magnesium and potassium aspartate, working together to support muscle function, electrolyte balance, and overall cardiovascular health. The generous quantity ensures optimal daily intake. The practical packaging is easy to store and consume, aiding not just muscle and heart health, but also nerve function and energy production. Overall, it's an essential for anyone wanting comprehensive mineral support.
Read More
9
Tangible benefits
1 people found this helpful
I purchased this supplement for my husband on a doctor's recommendation. The benefits are tangible; my night cramps diminished almost immediately and my sleep improved. It contains taurine for additional health support. The large packaging will last a long time, and the ingredients—magnesium, potassium, and taurine—are exactly what I need for cardiovascular and nervous system support. The quality is excellent, the capsules are manageable to swallow, and the taste is neutral. I recommend it.
Read More
9
Restores cardiovascular system
Excellent product quality with natural ingredients. The capsules are convenient in size. It aids the restoration of joints, muscles, and the proper functioning of the entire cardiovascular system.
Read More
6
Improved sleep
11 people found this helpful
I bought this for the prevention of cardiovascular issues as I have significant arrhythmia. I felt physical weakness before starting this. Since I began taking it, I feel more cheerful and my sleep has improved.
Read More
7.5
Improves heart function
4 people found this helpful
My family is very satisfied with the quality of this brand, and I keep repurchasing it. The combination of magnesium and potassium is advantageous. Magnesium not only improves sleep but also relieves muscle spasms, while potassium aids metabolism and maintains the body's balance. With a deficiency, there can be cardiovascular issues. My 70-year-old mother does not experience spasms now, and her heart functions better. The medium-sized, tasteless capsules last a month for four people; highly recommended!
Read More

Frequently Asked Questions

9
Tangible benefits
1 people found this helpful
I purchased this supplement for my husband on a doctor's recommendation. The benefits are tangible; my night cramps diminished almost immediately and my sleep improved. It contains taurine for additional health support. The large packaging will last a long time, and the ingredients—magnesium, potassium, and taurine—are exactly what I need for cardiovascular and nervous system support. The quality is excellent, the capsules are manageable to swallow, and the taste is neutral. I recommend it.
6
Improved sleep
11 people found this helpful
I bought this for the prevention of cardiovascular issues as I have significant arrhythmia. I felt physical weakness before starting this. Since I began taking it, I feel more cheerful and my sleep has improved.
7.5
Enhances endurance
2 people found this helpful
This preparation has a convenient dosage of two capsules a day. During use, I noticed a significant benefit on my cardiovascular system with normalised pulse and improved endurance. Although I recently learned that this form of magnesium may not be the best, I am pleased with its effects.
7.5
Improves heart function
4 people found this helpful
My family is very satisfied with the quality of this brand, and I keep repurchasing it. The combination of magnesium and potassium is advantageous. Magnesium not only improves sleep but also relieves muscle spasms, while potassium aids metabolism and maintains the body's balance. With a deficiency, there can be cardiovascular issues. My 70-year-old mother does not experience spasms now, and her heart functions better. The medium-sized, tasteless capsules last a month for four people; highly recommended!
6
Supports cardiovascular function
1 people found this helpful
I really appreciate the quality of this brand. Magnesium and potassium aspartate is excellently absorbed and I use it to support my husband's cardiovascular system. It also enhances sleep and alleviates anxiety. The large packaging is practical and the capsules are easy to swallow. It serves as a good alternative to pharmacist's drugs, being much cheaper yet of higher quality!
6
Specialised heart support
2 people found this helpful
For heart support, magnesium is effective for various heart diseases, but I believe it is specialised. This magnesium is intended for people with arrhythmia.
8
Magnesium linked to cardiovascular health
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.

We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.

This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
8
Magnesium's impact on HFpEF mortality
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.

Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.

While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.

This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
8
Magnesium linked to heart health
We explored the connection between dietary magnesium intake and cardiovascular disease, particularly in people living with diabetes. This study analyzed data from a large group of over 5,000 individuals who participated in the National Health and Nutrition Examination Survey over nearly two decades.

By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.

The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
We examined the effects of calcium, magnesium, and vitamin D supplementation in managing hypertension, a major risk factor for cardiovascular disease. Analyzing data from 40 studies, we discovered that both calcium and magnesium significantly lowered diastolic blood pressure (DBP) but showed no notable impact on systolic blood pressure (SBP) or pulse rates. Vitamin D, however, was effective in reducing both SBP and DBP. Our findings indicate that while calcium and magnesium can help manage hypertension, vitamin D may offer a more pronounced benefit in lowering blood pressure overall.

References

  1. Yu H, Zhou C, Yang S, Yu J, Zhang X, et al. Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium. Biomaterials. 2025;319:123135. doi:10.1016/j.biomaterials.2025.123135
  2. Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. doi:10.1093/ckj/sfae390
  3. Wang F, Mao Y, Sun J, Yang J, Xiao L, et al. Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes. Sci Rep. 2025;15:4600. doi:10.1038/s41598-025-88480-9
  4. Dong H, Lu N, Wang J, Hu P. Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease. Asia Pac J Clin Nutr. 2025;34:104. doi:10.6133/apjcn.202502_34(1).0010
  5. Song L, Ying J, Li M, Ying L, Zhao C. Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF. Sci Rep. 2025;15:1944. doi:10.1038/s41598-025-85931-1
  6. Nielsen FH. The Role of Dietary Magnesium in Cardiovascular Disease. Nutrients. 2024;16. doi:10.3390/nu16234223
  7. Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. doi:10.1684/mrh.2024.0528
  8. Urbanowicz T, Hanć A, Frąckowiak J, Piecek J, Spasenenko I, et al. The Hypothesis of Trace Elements Involvement in the Coronary Arteries Atherosclerotic Plaques' Location. J Clin Med. 2024;13. doi:10.3390/jcm13226933
  9. Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. doi:10.1161/JAHA.124.038870
  10. Shahsavani Z, Masoumi SJ, Barati-Boldaji R, Shamshirgardi E, Kafipour R, et al. Dietary Calcium to Magnesium Ratio and Risk of Cardiovascular Diseases. Biol Trace Elem Res. 2025. doi:10.1007/s12011-025-04587-0
  11. Pariona-Vargas F, Mun KT, Lo EH, Starkman S, Sanossian N, et al. Is there diurnal variation in neuroprotective and thrombolytic therapy effect upon acute cerebral ischemia outcome?. J Stroke Cerebrovasc Dis. 2025;34:108278. doi:10.1016/j.jstrokecerebrovasdis.2025.108278
  12. Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. doi:10.1186/s12906-025-04809-x
  13. Kumawat A, Tavazzani E, Lentini G, Trancuccio A, Kukavica D, et al. Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations. J Biomed Sci. 2025;32:40. doi:10.1186/s12929-025-01134-w
  14. Ishigami J, Hasan MM, Sarker A, Nahar S, Shuvo SS, et al. Dyskalemia Prior to and After Initiation of a Fixed Dose Combination of Telmisartan and Amlodipine in Adults with Hypertension in Bangladesh. Glob Heart. 2025;20:30. doi:10.5334/gh.1415
  15. Pang ZD, Wang Y, Han MZ, She G, Sun X, et al. AMPK phosphorylation of K2.3 alleviates angiotensin II-induced endothelial dysfunction. Biochem Pharmacol. 2025;236:116880. doi:10.1016/j.bcp.2025.116880
  16. Peng JQ, Zhou MM, Xu L, Wang X, Tang YH, et al. Targeted M-Channel Activation in the Left Stellate Ganglion Protects Against Ischemia-Induced Ventricular Arrhythmias in Canines. J Am Heart Assoc. 2025;14:e039059. doi:10.1161/JAHA.124.039059
  17. Du X, Zhu Y, Guo J, Chen X, Zhang J, et al. Effect of Salt Reduction Interventions in Lowering Blood Pressure and Salt Intake in Zhejiang Province, China, 2017-2021: A Randomized Controlled Trial. Nutrients. 2025;17. doi:10.3390/nu17050893
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  21. Geng X, Feng Y, Yu C, Yao Y, Chen W, et al. Taurine supplementation decreases fat accumulation by suppressing FAS and enhancing ATGL through the ATGL pathway. Iran J Basic Med Sci. 2024;27:1529. doi:10.22038/ijbms.2024.76625.16590
  22. Tzang CC, Lin WC, Lin LH, Lin TY, Chang KV, et al. Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis. Nutr J. 2024;23:93. doi:10.1186/s12937-024-00995-5
  23. Mahmoud MM, El-Batran SA, Hegazy R, El-Sayed WM. Taurine and enzymatically modified isoquercitrin protected against methotrexate-induced deteriorations in the conductivity and rhythmicity of the heart in rats: Antioxidant, anti-inflammatory, and histological architecture approach. J Appl Toxicol. 2024;44:1924. doi:10.1002/jat.4682
  24. Li FJ, Abudureyimu M, Zhang ZH, Tao J, Ceylan AF, et al. Inhibition of ER stress using tauroursodeoxycholic acid rescues obesity-evoked cardiac remodeling and contractile anomalies through regulation of ferroptosis. Chem Biol Interact. 2024;398:111104. doi:10.1016/j.cbi.2024.111104
  25. Tzang CC, Chi LY, Lin LH, Lin TY, Chang KV, et al. Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Nutr Diabetes. 2024;14:29. doi:10.1038/s41387-024-00289-z
  26. Li Y, Gao YN, Zhu YB, Lu WF, Yu JY, et al. Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus. Food Funct. 2024;15:5088. doi:10.1039/d4fo00808a
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