We examined whether activating M-type potassium channels in the left stellate ganglion could help manage heart issues during acute myocardial ischemia (AMI). In our study involving beagles, some received an M-channel activator called retigabine before inducing AMI.
The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
Read More
8
Magnesium's impact on heart health
The Role of Dietary Magnesium in Cardiovascular Disease.
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Read More
8
Taurine improves heart health metrics
Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis.
We explored the potential benefits of taurine, an amino acid that could play a significant role in promoting cardiovascular health. Our investigation focused on how taurine treatment affects key aspects of heart function, including blood pressure, heart rate, and overall cardiac performance.
By analyzing data from several randomized controlled trials, we aimed to get a clearer picture of taurine's effects. Our study looked at important metrics such as systolic and diastolic blood pressure, heart rate, and the left ventricular ejection fraction, which are all critical indicators of heart health.
The findings indicated that taurine is helpful in preventing hypertension and can improve cardiac function, making it a beneficial addition for those at risk of cardiovascular diseases. Overall, incorporating taurine into daily routines might be advantageous for heart health, particularly for individuals prone to cardiovascular issues.
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Most Useful Reviews
9
Optimises cardiovascular health
1 people found this helpful
NOW Foods Magnesium & Potassium Aspartate is a robust supplement blend for overall health. Its neutral scent allows easy incorporation into daily life. The formulation combines magnesium and potassium aspartate, working together to support muscle function, electrolyte balance, and overall cardiovascular health. The generous quantity ensures optimal daily intake. The practical packaging is easy to store and consume, aiding not just muscle and heart health, but also nerve function and energy production. Overall, it's an essential for anyone wanting comprehensive mineral support.
Read More
9
Tangible benefits
1 people found this helpful
I purchased this supplement for my husband on a doctor's recommendation. The benefits are tangible; my night cramps diminished almost immediately and my sleep improved. It contains taurine for additional health support. The large packaging will last a long time, and the ingredients—magnesium, potassium, and taurine—are exactly what I need for cardiovascular and nervous system support. The quality is excellent, the capsules are manageable to swallow, and the taste is neutral. I recommend it.
Read More
9
Restores cardiovascular system
Excellent product quality with natural ingredients. The capsules are convenient in size. It aids the restoration of joints, muscles, and the proper functioning of the entire cardiovascular system.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
9
ICA-105574 shows promise for LQT2
Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations.
We investigated how ICA-105574, an HERG channel activator, might alleviate severe long QT syndrome type 2 (LQT2) caused by critical genetic mutations. Our study included in vivo experiments with animal models and in vitro tests that showcased ICA-105574's ability to shorten cardiac repolarization intervals.
We found it effectively restored ion currents impacted by harmful mutations. Our findings indicate that ICA-105574 has potential as a therapeutic option and highlight the usefulness of molecular dynamics simulations in drug design for managing HERG-related conditions.
Read More
9
AMPK activation improves endothelial function
AMPK phosphorylation of K2.3 alleviates angiotensin II-induced endothelial dysfunction.
We explored how AMPK, when activated, enhances potassium channels known as K2.3 in endothelial cells, which could improve vascular health. Through various laboratory techniques, we found that AMPK activation increased the phosphorylation of K2.3, leading to better blood flow in mouse models of hypertension. This process seems to reduce early hypertension caused by angiotensin II. Our findings suggest that AMPK could be a valuable target for therapies aimed at treating endothelial dysfunction and hypertension.
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9
M-channel activation mitigates arrhythmias
Targeted M-Channel Activation in the Left Stellate Ganglion Protects Against Ischemia-Induced Ventricular Arrhythmias in Canines.
We examined whether activating M-type potassium channels in the left stellate ganglion could help manage heart issues during acute myocardial ischemia (AMI). In our study involving beagles, some received an M-channel activator called retigabine before inducing AMI.
The results were promising—we noticed that retigabine reduced excessive sympathetic activity, leading to fewer arrhythmias. Moreover, it allowed for better heart rhythm stability and increased resistance to ventricular fibrillation compared to those who did not receive treatment. These insights suggest that targeting M-channels could be a valuable approach in reducing heart rhythm disturbances during ischemic events.
Read More
9
Taurine and EMIQ mitigate cardiotoxicity
Taurine and enzymatically modified isoquercitrin protected against methotrexate-induced deteriorations in the conductivity and rhythmicity of the heart in rats: Antioxidant, anti-inflammatory, and histological architecture approach.
We investigated how taurine (Tau) and enzymatically modified isoquercitrin (EMIQ) can help protect the heart from damage caused by methotrexate (MTX), a common cancer treatment associated with cardiotoxic effects. Our study involved adult male rats that were divided into several groups, each receiving different treatments. Among these groups, some rats were given MTX alone, while others received combinations of Tau and EMIQ alongside MTX.
Our findings revealed that MTX significantly impacted heart function, leading to abnormal heart rhythms and increased inflammation in cardiac tissues. Specifically, we saw changes in heart electrical signals, such as shortened intervals between heartbeats and an extended duration for the heart's repolarization process, indicating potential cardiac distress.
However, when we treated the rats with Tau and EMIQ, either alone or together, we observed an impressive protective effect against these adverse changes. Both treatments helped improve heart conductivity and rhythm, while also reducing inflammation and cell damage within the heart. This suggests that incorporating these compounds into treatment regimens might help mitigate some of the heart-related side effects of MTX therapy.
Our results highlight the potential benefits of taurine and EMIQ, particularly when used in combination, for maintaining heart health during cancer treatment. This research sheds light on promising nutritional approaches to counteract cardiotoxicity in cancer therapies.
NOW Foods Magnesium & Potassium Aspartate is a robust supplement blend for overall health. Its neutral scent allows easy incorporation into daily life. The formulation combines magnesium and potassium aspartate, working together to support muscle function, electrolyte balance, and overall cardiovascular health. The generous quantity ensures optimal daily intake. The practical packaging is easy to store and consume, aiding not just muscle and heart health, but also nerve function and energy production. Overall, it's an essential for anyone wanting comprehensive mineral support.
Read More
9
Tangible benefits
1 people found this helpful
I purchased this supplement for my husband on a doctor's recommendation. The benefits are tangible; my night cramps diminished almost immediately and my sleep improved. It contains taurine for additional health support. The large packaging will last a long time, and the ingredients—magnesium, potassium, and taurine—are exactly what I need for cardiovascular and nervous system support. The quality is excellent, the capsules are manageable to swallow, and the taste is neutral. I recommend it.
Read More
9
Restores cardiovascular system
Excellent product quality with natural ingredients. The capsules are convenient in size. It aids the restoration of joints, muscles, and the proper functioning of the entire cardiovascular system.
Read More
6
Improved sleep
11 people found this helpful
I bought this for the prevention of cardiovascular issues as I have significant arrhythmia. I felt physical weakness before starting this. Since I began taking it, I feel more cheerful and my sleep has improved.
Read More
7.5
Improves heart function
4 people found this helpful
My family is very satisfied with the quality of this brand, and I keep repurchasing it. The combination of magnesium and potassium is advantageous. Magnesium not only improves sleep but also relieves muscle spasms, while potassium aids metabolism and maintains the body's balance. With a deficiency, there can be cardiovascular issues. My 70-year-old mother does not experience spasms now, and her heart functions better. The medium-sized, tasteless capsules last a month for four people; highly recommended!
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is an essential mineral that plays a significant role in various bodily functions, including heart health. Research has shown that adequate magnesium intake can help regulate blood pressure, maintain normal heart rhythms, and support overall cardiovascular function. Some studies suggest that higher magnesium levels may be associated with a lower risk of cardiovascular disease, as magnesium helps to keep blood vessels dilated and can prevent harmful calcium buildup in arterial walls.
However, it’s important to note that while magnesium supplementation can be beneficial, it should not be seen as a standalone treatment for cardiovascular disease. A well-rounded approach that includes a balanced diet rich in magnesium (found in foods like leafy greens, nuts, seeds, and whole grains), regular physical activity, and maintaining a healthy weight is essential for optimal heart health. As always, it is best to consult with a healthcare provider before making any substantial changes to your diet or supplement routine, especially if you have existing heart conditions or other health concerns.
Based on user reviews, it appears that those taking this supplement for cardiovascular health often report positive effects relatively quickly. Some users have noted improvements in symptoms such as night cramps and sleep quality within days of starting the supplement (Read Review). Another individual highlighted feeling more cheerful and experiencing better sleep just after beginning their regimen, indicating that benefits can materialize swiftly (Read Review).
However, the timeline for noticeable changes can vary from person to person. One reviewer mentioned a significant improvement in cardiovascular function alongside better endurance, suggesting that while some effects may be immediate, others may take a bit longer to become apparent (Read Review). Overall, most users seem optimistic about the supplement's effects, often experiencing initial benefits within the first week or two following commencement of use.
Magnesium supplementation is increasingly being recognized as a promising addition to cardiovascular health regimens, backed by extensive scientific research. Various studies suggest that magnesium plays a critical role in reducing the risk of cardiovascular diseases. For instance, higher serum magnesium levels have been associated with reduced mortality from cardiovascular conditions among patients with chronic kidney disease, showing that maintaining adequate magnesium levels could be vital for heart health [2]. Additionally, magnesium supplements have demonstrated potential benefits for patients with heart failure with preserved ejection fraction, significantly lowering mortality rates within the first 28 days of treatment [5].
Furthermore, magnesium’s impact on conditions like diabetes and hypertension indicate its multifaceted benefits. Studies have shown that higher dietary magnesium intake is linked to lower cardiovascular mortality among diabetic patients [3] and that magnesium can help manage blood pressure effectively [12]. While these findings are encouraging, further research is warranted to solidify our understanding of magnesium's role in cardiovascular disease prevention and management. Overall, a consistent theme across studies suggests that incorporating adequate magnesium through diet or supplementation may enhance heart health and reduce associated risks.
Based on user reviews, many individuals have reported noticeable improvements in several health aspects after using NOW Foods Magnesium & Potassium Aspartate. For instance, one user mentioned a substantial reduction in night cramps and a marked enhancement in sleep quality shortly after starting the supplement, attributing these benefits to the magnesium and potassium formulation (Read Review). Others remarked on feeling more cheerful and experiencing improved sleep, particularly those dealing with cardiovascular concerns such as arrhythmia (Read Review).
Moreover, reviewers frequently noted the supplement's positive effects on cardiovascular health. One user reported improved endurance and stable pulse rates, which suggests significant cardiovascular benefits during use (Read Review). Another user highlighted that the combination of magnesium and potassium effectively alleviated muscle spasms and supported overall heart function, citing their 70-year-old mother’s improvement in cardiovascular health (Read Review). While these anecdotal experiences showcase beneficial outcomes, it's essential to note that individual results can vary, and not every user may experience the same level of efficacy.
Users have reported positive experiences when combining NOW Foods Magnesium & Potassium Aspartate with other supplements for managing cardiovascular disease. Several reviewers noted that the synergistic effects of magnesium and potassium have greatly benefited heart health. One user emphasized the product's effectiveness for their husband’s cardiovascular support, mentioning improvements in overall function and relief from muscle spasms, which are often linked to cardiovascular issues (Read Review).
Additionally, some users specifically highlighted the formulation's enhancement of cardiovascular health alongside other health benefits. For instance, a reviewer noted that these supplements not only help in restoring the cardiovascular system's functionality but also improve sleep quality and alleviate anxiety (Read Review). Another user with arrhythmia observed a general feeling of cheerfulness and better sleep after incorporating the supplement into their regimen (Read Review). Overall, users seem to suggest that the combination of magnesium and potassium works well for cardiovascular health, particularly for those with specific conditions like arrhythmia and muscle spasms.
Users report that a typical effective dose for magnesium when treating cardiovascular disease often involves taking two capsules per day, which has yielded significant benefits such as normalised pulse and improved endurance for many consumers Read Review. The combination of magnesium and potassium is noted by users to be particularly advantageous. Reviewers highlight that these supplements help alleviate issues like muscle spasms and contribute positively to heart function, suggesting that regular intake can prevent cardiovascular concerns, especially in individuals with existing conditions such as arrhythmia Read ReviewRead Review.
While user reviews endorse the efficacy of magnesium for cardiovascular health, the specifics of dosage can vary, and some users express that it is best when tailored to individual needs Read Review. More importantly, users suggest seeking advice from healthcare professionals to determine the optimal dosage and formulation for their personal health conditions Read Review. Overall, for those considering magnesium for heart support, a balanced approach that includes professional guidance is highly recommended.
9
Tangible benefits
1 people found this helpful
I purchased this supplement for my husband on a doctor's recommendation. The benefits are tangible; my night cramps diminished almost immediately and my sleep improved. It contains taurine for additional health support. The large packaging will last a long time, and the ingredients—magnesium, potassium, and taurine—are exactly what I need for cardiovascular and nervous system support. The quality is excellent, the capsules are manageable to swallow, and the taste is neutral. I recommend it.
6
Improved sleep
11 people found this helpful
I bought this for the prevention of cardiovascular issues as I have significant arrhythmia. I felt physical weakness before starting this. Since I began taking it, I feel more cheerful and my sleep has improved.
7.5
Enhances endurance
2 people found this helpful
This preparation has a convenient dosage of two capsules a day. During use, I noticed a significant benefit on my cardiovascular system with normalised pulse and improved endurance. Although I recently learned that this form of magnesium may not be the best, I am pleased with its effects.
7.5
Improves heart function
4 people found this helpful
My family is very satisfied with the quality of this brand, and I keep repurchasing it. The combination of magnesium and potassium is advantageous. Magnesium not only improves sleep but also relieves muscle spasms, while potassium aids metabolism and maintains the body's balance. With a deficiency, there can be cardiovascular issues. My 70-year-old mother does not experience spasms now, and her heart functions better. The medium-sized, tasteless capsules last a month for four people; highly recommended!
6
Supports cardiovascular function
1 people found this helpful
I really appreciate the quality of this brand. Magnesium and potassium aspartate is excellently absorbed and I use it to support my husband's cardiovascular system. It also enhances sleep and alleviates anxiety. The large packaging is practical and the capsules are easy to swallow. It serves as a good alternative to pharmacist's drugs, being much cheaper yet of higher quality!
6
Specialised heart support
2 people found this helpful
For heart support, magnesium is effective for various heart diseases, but I believe it is specialised. This magnesium is intended for people with arrhythmia.
8
Magnesium linked to cardiovascular health
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
8
Magnesium's impact on HFpEF mortality
Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
8
Magnesium linked to heart health
Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes.
We explored the connection between dietary magnesium intake and cardiovascular disease, particularly in people living with diabetes. This study analyzed data from a large group of over 5,000 individuals who participated in the National Health and Nutrition Examination Survey over nearly two decades.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
5
Calcium and magnesium aid DBP
Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis.
We examined the effects of calcium, magnesium, and vitamin D supplementation in managing hypertension, a major risk factor for cardiovascular disease. Analyzing data from 40 studies, we discovered that both calcium and magnesium significantly lowered diastolic blood pressure (DBP) but showed no notable impact on systolic blood pressure (SBP) or pulse rates. Vitamin D, however, was effective in reducing both SBP and DBP. Our findings indicate that while calcium and magnesium can help manage hypertension, vitamin D may offer a more pronounced benefit in lowering blood pressure overall.
References
Yu H, Zhou C, Yang S, Yu J, Zhang X, et al. Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium. Biomaterials. 2025;319:123135. doi:10.1016/j.biomaterials.2025.123135
Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. doi:10.1093/ckj/sfae390
Wang F, Mao Y, Sun J, Yang J, Xiao L, et al. Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes. Sci Rep. 2025;15:4600. doi:10.1038/s41598-025-88480-9
Dong H, Lu N, Wang J, Hu P. Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease. Asia Pac J Clin Nutr. 2025;34:104. doi:10.6133/apjcn.202502_34(1).0010
Song L, Ying J, Li M, Ying L, Zhao C. Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF. Sci Rep. 2025;15:1944. doi:10.1038/s41598-025-85931-1
Nielsen FH. The Role of Dietary Magnesium in Cardiovascular Disease. Nutrients. 2024;16. doi:10.3390/nu16234223
Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. doi:10.1684/mrh.2024.0528
Urbanowicz T, Hanć A, Frąckowiak J, Piecek J, Spasenenko I, et al. The Hypothesis of Trace Elements Involvement in the Coronary Arteries Atherosclerotic Plaques' Location. J Clin Med. 2024;13. doi:10.3390/jcm13226933
Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. doi:10.1161/JAHA.124.038870
Shahsavani Z, Masoumi SJ, Barati-Boldaji R, Shamshirgardi E, Kafipour R, et al. Dietary Calcium to Magnesium Ratio and Risk of Cardiovascular Diseases. Biol Trace Elem Res. 2025. doi:10.1007/s12011-025-04587-0
Pariona-Vargas F, Mun KT, Lo EH, Starkman S, Sanossian N, et al. Is there diurnal variation in neuroprotective and thrombolytic therapy effect upon acute cerebral ischemia outcome?. J Stroke Cerebrovasc Dis. 2025;34:108278. doi:10.1016/j.jstrokecerebrovasdis.2025.108278
Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. doi:10.1186/s12906-025-04809-x
Kumawat A, Tavazzani E, Lentini G, Trancuccio A, Kukavica D, et al. Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations. J Biomed Sci. 2025;32:40. doi:10.1186/s12929-025-01134-w
Ishigami J, Hasan MM, Sarker A, Nahar S, Shuvo SS, et al. Dyskalemia Prior to and After Initiation of a Fixed Dose Combination of Telmisartan and Amlodipine in Adults with Hypertension in Bangladesh. Glob Heart. 2025;20:30. doi:10.5334/gh.1415
Pang ZD, Wang Y, Han MZ, She G, Sun X, et al. AMPK phosphorylation of K2.3 alleviates angiotensin II-induced endothelial dysfunction. Biochem Pharmacol. 2025;236:116880. doi:10.1016/j.bcp.2025.116880
Peng JQ, Zhou MM, Xu L, Wang X, Tang YH, et al. Targeted M-Channel Activation in the Left Stellate Ganglion Protects Against Ischemia-Induced Ventricular Arrhythmias in Canines. J Am Heart Assoc. 2025;14:e039059. doi:10.1161/JAHA.124.039059
Du X, Zhu Y, Guo J, Chen X, Zhang J, et al. Effect of Salt Reduction Interventions in Lowering Blood Pressure and Salt Intake in Zhejiang Province, China, 2017-2021: A Randomized Controlled Trial. Nutrients. 2025;17. doi:10.3390/nu17050893
Liebman SE, Baran A, Barnett TD, Campbell TM, Chen L, et al. The Effects of a Whole-Food Plant-Based Nutrition Education Program on Blood Pressure and Potassium in Chronic Kidney Disease: A Proof-of-Concept Study. Nutrients. 2025;17. doi:10.3390/nu17050779
Zhang X, Yao S, Wang Y, Chu C, Du M, et al. Associations of microRNA Gene Polymorphisms With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Hypertension Incidence in the Chinese Population. J Clin Hypertens (Greenwich). 2025;27:e70019. doi:10.1111/jch.70019
Chen B, Bao R, Pan J, Zhu Z, Chen Q, et al. Taurine alleviates dysfunction of cholesterol metabolism under hyperuricemia by inhibiting A2AR-SREBP-2/CREB/HMGCR axis. J Lipid Res. 2025;66:100746. doi:10.1016/j.jlr.2025.100746
Geng X, Feng Y, Yu C, Yao Y, Chen W, et al. Taurine supplementation decreases fat accumulation by suppressing FAS and enhancing ATGL through the ATGL pathway. Iran J Basic Med Sci. 2024;27:1529. doi:10.22038/ijbms.2024.76625.16590
Tzang CC, Lin WC, Lin LH, Lin TY, Chang KV, et al. Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis. Nutr J. 2024;23:93. doi:10.1186/s12937-024-00995-5
Mahmoud MM, El-Batran SA, Hegazy R, El-Sayed WM. Taurine and enzymatically modified isoquercitrin protected against methotrexate-induced deteriorations in the conductivity and rhythmicity of the heart in rats: Antioxidant, anti-inflammatory, and histological architecture approach. J Appl Toxicol. 2024;44:1924. doi:10.1002/jat.4682
Li FJ, Abudureyimu M, Zhang ZH, Tao J, Ceylan AF, et al. Inhibition of ER stress using tauroursodeoxycholic acid rescues obesity-evoked cardiac remodeling and contractile anomalies through regulation of ferroptosis. Chem Biol Interact. 2024;398:111104. doi:10.1016/j.cbi.2024.111104
Tzang CC, Chi LY, Lin LH, Lin TY, Chang KV, et al. Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Nutr Diabetes. 2024;14:29. doi:10.1038/s41387-024-00289-z
Li Y, Gao YN, Zhu YB, Lu WF, Yu JY, et al. Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus. Food Funct. 2024;15:5088. doi:10.1039/d4fo00808a